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François Goffinet
Gynécologue Obstétricien
Photo of François Goffinet

Professor of Obstetrics and Gynecology, Head of the obstetrics department at the Port-Royal Maternity Hospital (University of Paris Descartes).
Researcher in perinatal epidemiology, INSERM U1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Research Center for Epidemiology and Biostatistics Sorbonne Paris Cité (CRESS), Paris Descartes University, Paris, France.
Director of the Département Hospitalo-Universitaire (DHU: certified center of excellence) on Risks and Pregnancy, which brings together clinical departments, laboratories, and research groups working on preterm birth, vascular diseases of pregnancy (preeclampsia and fetal growth restriction), diseases associated with infections and inflammation, and those associated with social and economic vulnerability. The DHU comprises 80 physicians, 92 researchers, 50 doctoral students, and 15 post-doctoral fellows.
Scientific advisor to the Paris Registry of Congenital Malformations.


François Goffinet, 54 years, is Professor of Gynecology and Obstetrics since 2002 (Paris-Descartes University) and head of the maternité Port-Royal (Paris, France). He received his Medical Degree (Paris, France) in 1995 and his Ph.D. in Public Health at the University of Paris-Sud in 1998. He was the Director of the INSERM U953 – Epidemiological Research Unit on Perinatal Health and Women’s and Children Health (2009-2013). The aim of the unit is the Research on clinical epidemiology in the perinatal field with different methods (randomised controlled trials, non interventionnal prospective studies, case-control studies). Since 2012, he directs the DHU Risk in pregnancy. This department brings together clinical departments, laboratories and research units to advance both our knowledge and our care of the major perinatal diseases that affect mothers and children. The DHU focuses on four major themes in perinatal health: preterm delivery, vascular diseases of pregnancy (preeclampsia and intrauterine fetal growth restriction), infectious or inflammatory diseases of pregnancy, and those linked to economic and social vulnerability or insecurity, regardless of the cause.

Principal ongoing projects (2014-)

Principal investigator

  • EPICARD Cohort: Principal investigator. Study of the outcomes of children with severe congenital heart disease. Population-based cohort study in the Paris metropolitan region. Sponsor: Ministry of Health, 3 national hospital clinical grants (PHRC), 2004 (262 000 €) , 2008 (365 000 €) and 2011 (290 000 €). Scientific director: B Khoshnood. study period: 2005-2017.
  • MOMASSI project : Severe Maternal morbidity in PMSI : Developpment and testing a new tool to assess obstetric care – Sponsor: Ministry of Health, Regional Grant PREPS project-2013, (231 000 €). Scientific director: Catherine Deneux-Tharaux. Study Period : 2014-2018.

Scientific director or Director of methods and analysis

  • JUMODA: National prospective study comparing the mode of delivery of women with twins. Neonatal and maternal health consequences of planned mode of delivery. Principal Investigator: Thomas Schmitz. National PHRC 2012 (477 000 €). Study period 2014-2016.
  • REDIFF Study: Prognostic value of cerebral MRI with a study of its dissemination in practice for the prenatal assessment of fetuses with intrauterine growth restriction. Principal investigator: Pr Jouannic. Regional PHRC. Study period 2014-2017.
  • TRAKR Cohort: Director of methods and analysis. Immunologic, metagenomic, metabolic, and early environmental factors in the progression of type 1 diabetes. Scientific director: R Malone. Study period 2015-2019.
  • COL-STREPTOB Cohort: Director of methods and analysis. Study of intestinal colonization of newborns by the group B streptococcus ST-17 Sponsor: Ministry of Health, National hospital clinical grants (PHRC) (467 000 €). Principal investigator: Pr C Poyart.. Study period 2012-2016.
  • Scientific co-director: BREMEAVAC project: Search for excretion of measles vaccine virus in the milk of women vaccinated in the immediate postpartum period with the MMR trivalent vaccine. Principal investigator: Pr O Launay. National PHRC 2013. Study period: 2014-2016.

Education and Diplomas

D.E.S. in gynecology and obstetrics: 1995 Université Paris-Descartes
DEA in public health: 1994, Université Paris XI
Doctoral dissertation in Public Health: 1998, Université Paris XI
Habilitation à Diriger des Recherches (accreditation to supervise research): 1998 Université Paris-Descartes

Recent selected peer-review publications

Schmitz T, Prunet C, Azria E, Bohec C, Bongain A, Chabanier P, DʼErcole C, Deruelle P, De Tayrac R, Dreyfus M, Dupont C, Gondry J, Graesslin O, Kayem G, Langer B, Marpeau L, Morel O, Parant O, Perrotin F, Pierre F, Poulain P, Riethmuller D, Rozenberg P, Rudigoz RC, Sagot P, Sénat MV, Sentilhes L, Vayssière C, Venditelli F, Verspyck E, Winer N, Lecomte-Raclet L, Ancel PY, Goffinet F; JUmeaux MODe dʼAccouchement (JUMODA) Study Group and the Groupe de Recherche en Obstétrique et Gynécologie (GROG). Association Between Planned Cesarean Delivery and Neonatal Mortality and Morbidity in Twin Pregnancies. Obstet Gynecol. 2017 Jun;129(6):986-995.

Delorme P, Goffinet F, Ancel PY, Foix-LʼHélias L, Langer B, Lebeaux C, Marchand LM, Zeitlin J, Ego A, Arnaud C, Vayssiere C, Lorthe E, Durrmeyer X, Sentilhes L, Subtil D, Debillon T, Winer N, Kaminski M, DʼErcole C, Dreyfus M, Carbonne B, Kayem G. Cause of Preterm Birth as a Prognostic Factor for Mortality. Obstet Gynecol. 2016;127:40-8.

Bartolo S, Goffinet F, Blondel B, Deneux-Tharaux C. Why women with previous caesarean and eligible for a trial of labour have an elective repeat caesarean delivery? A national study in France. BJOG. 2016 Apr 29.

Ancel PY, Goffinet F; and the EPIPAGE-2 Writing Group. Survival and Morbidity of Preterm Children Born at 22 Through 34 Weeks’ Gestation in France in 2011: Results of the EPIPAGE-2 Cohort Study. JAMA Pediatr. 2015 Jan 26.

Schmitz T, Fuchs F, Closset E, Rozenberg P, Winer N, Perrotin F, Verspyck E, Azria E, Carbonne B, Lepercq J, Maillard F, Goffinet F; for the Groupe de Recherche en Obstétrique et Gynécologie (GROG). Outpatient Cervical Ripening by Nitric Oxide Donors for Prolonged Pregnancy: A Randomized Controlled Trial.Obstet Gynecol. 2014 Dec;124(6):1089-1097.

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