Theses from 2009 to now

Current theses

Student Director Subject
Adrien Aubert J Zeitlin Motor difficulties among children born extremely preterm: risk factors and consequences for quality of life.
Jonathan Beck P-Y Ancel, N Bednarek Prognosis of hypoxic-ischemic encephalopathy: what can the clinical-biological-electroencephalographic and MRI markers bring us? (LyTONEPAL national cohort)
Neil Derridj B Khoshnood Neuro-developemental outcomes and quality of life of children with congenital heart defects : A prospective population based cohort study ( EPICARD )
Thomas Desplanches B Blondel, J Fresson Regionalization of care for very preterm birth.
Rym El Rafei J Zeitlin Postnatal growth and neurodevelopmental outcomes of very preterm children in Europe.
Maxime Eslier E Azria, C Deneux-Tharaux Migration and severe maternal morbidity.
Amanda Garrison F Bodeau-Livinec Parasitic infection during pregnancy and early childhood and neurocognitive development in children at 6 years in Benin.
Ali Ghanchi B Khoshnood, L Salomon Congenital anomalies, fetal growth restriction and post natal growth of children born with a congenital heart defect : a population based study.
Sandra Herrera A Germa Risk factors of palatal deformation and posterior crossbite at 5 years in very preterm infants and in general population.
Alice Hocquette J Zeitlin Definition of fetal growth restriction in Europe, growth references and association with risks of mortality and morbidity.
Elodie Lebreton J Zeitlin Evaluation of the quality and organization of neonatal care in the Ile-de-France region using validated hospital indicators of morbidity and mortality
Mathilde Letouzey L Foix-L’Hélias, E Lorthe Late-onset sepsis in very preterm infants in EPIPAGE-2 cohort study
Hugo Madar C Deneux-Tharaux,
L Sentilhes
Marqueurs diagnostiques et facteurs prédictifs d’hémorragie du post-partum
Diagnostic markers and predictive factors of postpartum hemorrhage
Jade Merrer MP Bonnet, A Chantry Analgesia for obstetrical labor and maternal satisfaction.
Robert Reed PY Ancel, J Zeitlin Building and validating a predictive risk model for 30-day readmission amongst pre-term infants in France.
Ayesha Siddiqi C Deneux-Tharaux, E Azria Associations between maternal origin, body mass index, and severe maternal morbidity.

Claire Thuillier G Kayem, P Rozenberg Screening and diagnosis of placenta accreta in high risk women.


Student Director Subject
Aude Girault C Le Ray Active management of labour in women with spontaneous onset of labour.


Student Director Subject
Shukrullah Ahmadi F Bodeau-Livinec Lead exposure in children, sources of exposure, and child growth in Benin.

Marie Chevalier T Debillon, PY Ancel Intraventricular hemorrhages of premature newborns, prevention and future.
Pierre Delorme G Kayem, F Goffinet Impact of the cause of premature delivery on the prognosis of the child.
Diane Korb T Schmitz,
C Deneux-Tharaux
Risk of severe acute maternal morbidity in women with twin pregnancies

Fleur Lorton M Chalumeau,
E Launay
Epidemiology of community-onset severe bacterial infections in children.

Anna-Veera Seppänen J Zeitlin Impact of socioeconomic factors on follow-up and health service use up to the age of 5 in a European cohort of children born very preterm.

Nhung Trinh M Chalumeau,
J Cohen
Outpatient antibiotic utilization monitoring: Methodological issues and application to pediatric outpatients in France.


Student Director Subject
Pauline Blanc-Petitjean C Le Ray The induction of labor in France: inventory of practices and evaluation of perinatal outcomes.

Caroline Diguisto F Goffinet,
L Foix-L’Hélias
Antenatal management and neonatal consequences among extremely preterm children.

Ayoub Mitha V Pierrat Breastfeeding at discharge of prematurely born children and unit policies: data from the EPIPAGE 2 cohort.


Student Director Subject
Anne-Sylvia Sacri M Chalumeau Iron deficiency in young children: prevalence, preventive and diagnostic strategies.

Héloise Torchin PY Ancel Déterminants précoces de la dysplasie broncho-pulmonaire chez les grands prématurés.

Solène Vigoureux MJ Saurel-Cubizolles
V Ringa
Employment during pregnancy. Social, occupational and medical determinants of occupational leave. Evolution between 1972 and 2016.


Student Director Subject
Marie Delnord J Zeitlin Variations spatio-temporelles de la prématurité et de la mortalité associée : une étude comparative dans 32 pays.

  • Are risk factors for live singleton preterm and early term birth the same? A population-based study in France. [in press at BMJ Open].
  • International variations in the gestational age distribution of births: an ecological study in 34 high-income countries. European Journal of Public Health, ckx131, Epub 2017 Sept 8.
  • Variations in very preterm birth rates in 30 high-income countries: are valid international comparisons possible using routine data? BJOG. 2016 Sep 10. doi: 10.1111/1471-0528.14273.
  • What contributes to disparities in the preterm birth rate in European countries? Curr Opin Obstet Gynecol. 2015 Feb 17.
Elsa Lorthe G Kayem Rupture prématurée des membranes avant 33 semaines d’aménorrhée : prise en charge anténatale et déterminants du pronostic de l’enfant.

  • Impact of Latency Duration on the Prognosis of Preterm Infants after Preterm Premature Rupture of Membranes at 24 to 32 Weeks’ Gestation: A National Population-Based Cohort Study. Pediatr. 2017 Mar;182:47-52.e2.
  • Tocolysis after preterm premature rupture of membranes and neonatal outcome: a propensity-score analysis. Am J Obstet Gynecol. 2017 Apr 13. pii: S0002-9378(17)30516-1.


Student Director Subject
Nathalie Bertille M Chalumeau Pharmaco-épidémiologie du traitement symptomatique de la fièvre chez l’enfant.

  • Managing fever in children: a national survey of parents’ knowledge and practices in France. PLoS One 2013;8:e83469.
  • Symptomatic management of fever in children: a national survey of healthcare professionals’ practices in France. PLoS One 2015;10:e0143230
  • National cross-sectional study of nonsteroidal anti-inflammatory drugs use highlights differences between parents and professionals and prompts safety concerns. Acta Paediatr 2016;105:e543-e8.
  • Enduring large use of acetaminophen suppositories for fever management in children: a national survey of French parents and healthcare professionals’ practices. Eur J Pediatr 2016;175:987-92.
  • Fever phobia 35 years later: did we fail? Acta Paediatr 2016;105:9-10.
Emilie Courtois R Carbajal Prise en charge de la douleur lors de gestes infirmiers avec effraction cutanée en réanimation néonatale. Étude Epipain 2

  • The burden of venipuncture pain in neonatal intensive care units: EPIPPAIN 2, a prospective observational study. Int J Nurs Stud 2016;57:48–59.
  • Epidemiology and neonatal pain management of heelsticks in intensive care units: EPIPPAIN 2, a prospective observational study. Int J Nurs Stud 2016;59: 79–88.
Isabelle Guellec PY Ancel Croissance (anté et postnatale) et devenir neurologique chez les enfants prématurés.

  • Intrauterine growth restriction, head size at birth and outcome in very preterm infants. J Pediatr 2015;167:975-981.
  • Effect of intra- and extrauterine growth on long term neurologic outcomes of very preterm infants. J Pediatr 2016;175:93-99.
Romain Guedj R Carbajal Crise convulsive fébrile aux urgences pédiatriques : risque de maladie infectieuse grave du système nerveux central.

  • Risk of bacterial meningitis in children 6 to 11 months of age with a first simple febrile seizure: a retrospective, cross-sectional observational study. Acad Emerg Med 2015;22:1290-7.
  • Do all children who present a complex febrile seizure need a lumbar puncture? Ann Emerg Med 2017 in press
Isabelle Monier J Zeitlin Dépistage anténatal du retard de croissance intra-utérin en France : évaluation, déterminants et impact sur les issues périnatales.

  • Does the presence of risk factors for fetal growth restriction increase the probability of antenatal detection? A French National Study. Paediatr Perinat Epidemiol. 2016;30:46-55.
  • Poor effectiveness of antenatal detection of fetal growth restriction and consequences for obstetric management and neonatal outcomes: a French national study. BJOG. 2015;122:518-27.
  • Gestational age at diagnosis of early onset of fetal growth restriction and impact on management and survival: a population-based cohort study. BJOG in press
Pauline Scherdel M Chalumeau, B Heude Surveillance de la croissance comme outil de repérage chez l’enfant.

  • Growth monitoring: a survey of current practices of primary care paediatricians in Europe. PLoS One, 2013;8:e70871.
  • Should the WHO growth charts be used in France? PLoS One, 2015;10:e0120806.
  • Growth monitoring as an early detection tool: a systematic review. Lancet Diabetes Endocrinology, 2016;4:447‐56.


Student Director Sujet / Publications
Mayass El Ayoubi J Zeitlin
Retard de croissance intra-utérin chez les grands prématurés : caractéristiques et impact sur la morbidité
  • Impact of fetal growth restriction on neurodevelopmental outcome at 2 years for extremely preterm infants: a single institution study. J Dev Med Child Neurol 2016;58:1249-56.
  • Does the antenatal detection of fetal growth restriction (FGR) have a prognostic value for mortality and short term morbidity for very preterm infants? Results from the MOSAIC cohort. J Matern Fetal Neonatal Med 2016;29:596-601.
  • Impact of fetal growth restriction on mortality and morbidity in a very preterm birth cohort. J Pediatr 2010;157:733-9
Elise Launay M Chalumeau
Méthodologies d’évaluation des soins: exemples des délais diagnostiques et des infections sévères chez l’enfant
  • Inadequate critical appraisal of studies in systematic reviews of time to diagnosis.
    J Clin Epidemiol 2016
  • Why children with severe bacterial infections die : a population-based study of determinants and consequences of suboptimal care with a special emphasis on methodological issues. PLoS One. 2014 Sep 23;9(9):e10728
  • Quality of reporting of studies evaluating time to diagnosis: a systematic review in paediatrics. Arch Dis Child 2014;99:244-50
Monica Saucedo C Deneux-Tharaux
Mortalité maternelle en France: profil épidémiologique, déterminants, amélioration de la mesure
  • Pitfalls of national routine death statistics for maternal mortality study. Paediatr Perinat Epidemiol 2014;28:479-88.
  • Ten years of confidential inquiries into maternal deaths in France, 1998-2007. Obstet Gynecol 2013;122:752-60.
  • Understanding regional differences in maternal mortality: a national case-control study in France. BJOG. 2011;119:573-81.


Student Director Subject / Publications
Marie-Pierre Bonnet M-H Bouvier-Colle,
D Deneux-Tharaux
Hémorragie du post partum: évaluation des pratiques d’anesthésie-réanimation
  • Postpartum haemorrhage in Canada and France: a population-based comparison.
    PLoS One. 2013 Jun 24;8(6):e66882.
  • Transfusion practices in postpartum hemorrhage: a population-based study.
    Acta Obstet Gynecol Scand. 2013 Apr;92(4):404-13.
  • Critical care and transfusion management in maternal deaths from postpartum haemorrhage.
    Eur J Obstet Gynecol Reprod Biol. 2011 Oct;158(2):183-8.
Jean-François Brasme M Chalumeau
Epidémiologie des délais diagnostiques des cancers de l’enfant : distribution, déterminants et conséquences médicales et juridiques
  • Time to diagnosis of Ewing tumors in children and adolescents is not associated with metastasis or survival: a prospective multicenter study of 436 patients.
    J Clin Oncol. 2014;32:1935-40.
  • Evidence of increasing mortality with longer time to diagnosis of cancer: is there a paediatric exception?
    Eur J Cancer. 2014;50:864-6.
  • Delays in diagnosis of paediatric cancers: a systematic review and comparison with expert testimony in lawsuits.
    Lancet Oncol. 2012;13:e445-59.
  • Long time to diagnosis of medulloblastoma in children is not associated with decreased survival or with worse neurological outcome.
    PLoS One. 2012;7:e33415.
  • Interval between onset of symptoms and diagnosis of medulloblastoma in children: distribution and determinants in a population-based study.
    Eur J Pediatr. 2012;171:25-32.
Jérémie Cohen M Chalumeau
Stratégies diagnostiques des pharyngites de l’enfant: du test de diagnostic rapide aux règles de décision clinique
  • Rapid antigen detection test for group A streptococcus in children with pharyngitis (Protocol).
    Cochrane Database of Systematic
    Reviews 2013, Issue 4. Art. No.: CD010502. DOI:10.1002/14651858.CD010502.
  • Rapid-antigen detection tests for group A streptococcal pharyngitis: revisiting false-positive results using PCR testing.
    The Journal of Pediatrics. 2013;162(6):1282-1284.
  • Effect of clinical spectrum, inoculum size and physician characteristics on sensitivity of a rapid antigen detection test for group A streptococcal pharyngitis.
    European Journal of Clinical Microbiology and Infectious Diseases. 2013;32(6):787-793.
  • Spectrum and inoculum size effect of a rapid antigen detection test for group A streptococcus in children with pharyngitis.
    PLoS One 2012; 7(6): e39085.
Xavier Durrmeyer R Carbajal
Prémédication avant l’intubation néonatale
  • Assessment of atropine-sufentanil-atracurium anaesthesia for endotracheal intubation: an observational study in very premature infants.BMC Pediatr. 2014 May 7;14:120.
  • Two-year outcomes of a randomized controlled trial of inhaled nitric oxide in premature infants.
    Pediatrics. 2013 Sep;132(3):e695-703.
  • Premedication for neonatal endotracheal intubation: results from the epidemiology of procedural pain in neonates study.
    Pediatr Crit Care Med. 2013 May;14(4):e169-75.
Gladys Ibanez MJ Saurel-Cubizolles
Santé mentale des femmes et croissance de l’enfant pendant la grossesse et jusqu’à 3 ans du post partum.
  • Depression and anxiety in women during pregnancy and neonatal outcome: data from the EDEN mother-child cohort.
    Early Hum Dev. 2012;88:643-9
  • Prevalence and characteristics of women reporting poor mental health during pregnancy: Findings from the 2010 French National Perinatal Survey.
    Rev Epidem Santé pub 2015;63:85-95
Symplice Mbola Mbassi MH Bouvier-Colle
Mortalité maternelle dans les maternités de référence au Cameroun
  • Délai de prise en charge des complications obstétricales: étude dans 7 maternités au Cameroun.
    Med Trop (Mars). 2009;69:480-4
  • Use of routinely collected data to assess maternal mortality in seven tertiary maternity centers in Cameroon.
    Int J Gynaecol Obstet 2011;115:240-3.
Karim Tararbit B Khoshnood
Assistance médicale à la procréation et cardiopathies congénitales : études en population
  • Assessing the role of multiple pregnancies in the association between tetralogy of Fallot and assisted reproductive techniques: a path-analysis approach.
    Orphanet J Rare Dis. 2014;9:27.
  • Clinical and socioeconomic predictors of pregnancy termination for fetuses with congenital heart defects: a population-based evaluation.
    Prenat Diagn. 2013;33:179-86.
  • The risk for four specific congenital heart defects associated with assisted reproductive techniques: a population-based evaluation.
    Hum Reprod. 2013;28:367-74.
  • Risk of congenital heart defects associated with assisted reproductive technologies: a population-based evaluation.
    Eur Heart J. 2011;32:500-8.


Student Director Subject / Publications
Anne Chantry MH Bouvier-Colle
De la possibilité d’étudier la morbidité maternelle sévère dans les bases de données hospitalières
  • Hospital discharge data can be used for monitoring procedures and intensive care related to severe maternal morbidity.
    J Clin Epidemiol. 2011;64:1014-22.
  • Le programme de médicalisation du système d’information (PMSI) – processus de production des données, validité et sources d’erreurs dans le domaine de la morbidité maternelle sévère.
    RESP, 2012 vol. 60, n° 3, 2012/06, pages 177-188
  • Pregnancy-Related ICU Admissions in France: Trends in Rate and Severity, 2006-2009.
    Crit Care Med. 2015 Jan;43(1):78-86
Bénédicte Coulm B Blondel
Prise en charge médicale des grossesses à bas risque en France
  • Obstetric Interventions for Low-Risk Pregnant Women in France: Do Maternity Unit Characteristics Make a Difference?
    Birth 39:3 September 2012 39:183-191.
  • Durée de séjour en maternité après un accouchement par voie basse en France.
    J Gynecol Obstet Biol Reprod (Paris) 2013 42(1): 76-85.
  • Potential avoidability of planned cesarean sections in a French national database.
    Acta Obstet Gynecol Scand 2014 93:905-12
  • Elective induction of labour and maternal request : a national population-based study.
    BJOG 2016 123:2191-7.
Patrick Gérardin G Bréart
L’impact communautaire du Chikungunya à l’île de la Réunion
  • Perceived morbidity and community burden after a Chikungunya outbreak: the TELECHIK survey, a population-based cohort study.
    BMC medicine 2011;9:5.
  • Predictors of Chikungunya rheumatism: a prognostic survey ancillary to the TELECHIK cohort study.
    Arthritis research & therapy 2013;15(1):R9.
  • Perceived morbidity and community burden of chikungunya in La Reunion.
    Médecine tropicale : revue du Corps de santé colonial 2012 Mar;72 Spec No:76-82.
Paulina Lopez G Bréart
Facteurs de risque d’accouchement prématuré au Chili et stratégies de prévention primaire.
  • Sociodemographic characteristics of mother’s population and risk of preterm birth in Chile.
    Reprod Health. 2013;10:26.
  • Trends in gestational age and birth weight in Chile, 1991-2008. A descriptive epidemiological study.
    BMC Pregnancy Childbirth. 2012;12:121.


Student Director Subject / Publications
Alice Germa C Nabet,
M Kaminski
Santé bucco-dentaire et croissance maxillaire de l’enfant
  • Neonatal factors associated with alteration of palatal morphology in very preterm children: the EPIPAGE cohort study.
    Early Hum Dev 2012;88:413-20.
  • Impact of social and economic characteristics on orthodontic treatment among children and teenagers in France.
    Community dentistry and oral epidemiology 2010 Apr;38(2):171-9.
Cyrille Huchon A Fauconnier
Développement d’un auto-questionnaire pour le diagnostic des douleurs pelviennes aigues
  • Is a standardized questionnaire useful for tubal rupture screening in patients with ectopic pregnancy?
    Academic emergency medicine: official journal of the Society for Academic Emergency Medicine 2012 Jan;19(1):24-30.
  • Does this woman have adnexal torsion?
    Hum Reprod 2012 Aug;27(8):2359-64.
  • Triage using a self-assessment questionnaire to detect potentially life-threatening emergencies in gynecology.
    World journal of emergency surgery : WJES 2014;9:46.


Student Director Subject / Publications
Ghada El Beaino PY Ancel,
G Bréart
Lésions cérébrales en période néonatale et devenir de l’enfant grand prématuré aux âges de 5 et 8 ans
  • Predictors of the risk of cognitive deficiency in very preterm infants: the EPIPAGE prospective cohort.
    Acta Paediatr. 2011;100:370-8.
  • Predictors of cerebral palsy in very preterm infants: the EPIPAGE prospective population-based cohort study.
    Dev Med Child Neurol. 2010;52:e119-25.
Marie-Laure Charkaluk V Pierrat
Développement cognitif des prématurés, Epipage
  • The influence of fetal growth reference standards on assessment of cognitive and academic outcomes of very preterm children.
    The Journal of pediatrics 2012 Dec;161(6):1053-8.
  • Prediction for very preterm children: also for favourable neurodevelopmental outcome.
    Acta Paediatr 2012 Jul;101(7):e267-8.
  • Very preterm children free of disability or delay at age 2: predictors of schooling at age 8: a population-based longitudinal study.
    Early human development 2011 Apr;87(4):297-302.
Jean-Noël Vergnes C Nabet,
M Sixou
Grossesse et santé bucco-dentaire
  • Maternal dental caries and pre-term birth: results from the EPIPAP study.
    Acta Odontologica Scandinavica 2011 Jul;69(4):248-56.
  • Frequency and risk indicators of tooth decay among pregnant women in France: a cross-sectional analysis.
    PloS one 2012;7(5):e33296.
  • Perceived oral health and use of dental services during pregnancy: the MaterniDent study.
    Santé publique (Vandoeuvre-les-Nancy, France) 2013 May-Jun;25(3):281-92.


Student Director Subject / Publications
François Dubos M Chalumeau
Distinction des méningites bactériennes et virales de l’enfant aux urgences
  • Sensitivity of the bacterial meningitis score in 889 children with bacterial meningitis.
    The Journal of pediatrics 2008 Mar;152(3):378-82.
  • Distinguishing between bacterial and aseptic meningitis in children: European comparison of two clinical decision rules.
    Archives of disease in childhood 2010 Dec;95(12):963-7.
  • Serum procalcitonin level and other biological markers to distinguish between bacterial and aseptic meningitis in children: a European multicenter case cohort study.
    Archives of pediatrics & adolescent medicine 2008 Dec;162(12):1157-63.
  • Clinical decision rules for evaluating meningitis in children.
    Current opinion in neurology 2009 Jun;22(3):288-93.
Annie Serfaty G Bréart
Le réseau périnatal de l’est parisien (2008-2010): de l’évaluation des besoins à l’évaluation des résultats
  • Le réseau périnatal de l’Est parisien (2008-2010). Définition de la population concernée pour évaluer les besoins à couvrir par le réseau.
    Rev Epidemiol Santé Publique 2010 ; 58 : 127-138
  • From knowledge to planning considerations: a matrix to assess health needs for the perinatal network in eastern Paris.
    Eur J Public Health. 2011 ; 21 : 504-511


Student Director Subject / Publications
Mercedes Bonet B Blondel
Facteurs associés à l’initiation et à la durée de l’allaitement maternel en France et en Europe
  • Differential trends in breastfeeding according to maternal and hospital characteristics: results from the French National Perinatal Surveys.
    Acta Paediatr. 2007;96:1290-5.
  • Allaitement maternel exclusif et allaitement partiel en maternité: la situation en France en 2003.
    Arch Pediatr. 2008;15:1407-15.
  • Variations in breastfeeding rates for very preterm infants between regions and neonatal units in Europe: results from the MOSAIC cohort.
    Arch Dis Child Fetal Neonatal Ed. 2011;96:F450-2.
  • Evaluating regional differences in breast-feeding in French maternity units: a multi-level approach.
    Public Health Nutr. 2010;13:1946-54.
Xavier Fritel A Fauconnier
Impact des pratiques obstétricales sur l’incontinence urinaire de la femme de la grossesse à la ménopause

Thèse sur publications

Camille Le Ray F Goffinet
Influence des caractéristiques de la structure de soin sur la prise en charge obstétricale des femmes à bas risque en France
  • Level of perinatal care of the maternity unit and rate of cesarean in low-risk nulliparas.
    Obstet Gynecol. 2006;107:1269-77.
  • Elective induction of labor: failure to follow guidelines and risk of cesarean delivery.
    Acta Obstet Gynecol Scand. 2007;86:657-65.
  • Factors associated with the choice of delivery without epidural analgesia in women at low risk in France.
    Birth. 2008;35:171-8.
  • The influence of level of care on admission to neonatal care for babies of low-risk nullipara.
    Eur J Obstet Gynecol Reprod Biol. 2009;144:21-6.